Questions and Answers (2022)

  1. Many leading analytical balance manufacturers provide built-in "auto-calibration" features in their balances. Are such auto-calibration procedures acceptable instead of external performance checks? If not, then what should the schedule for calibration be?

  2. Is there a list of CDER-approved drug manufacturing equipment?

  3. Can Total Organic Carbon (TOC) be an acceptable method for detecting residues of contaminants in evaluating cleaning effectiveness?

  4. A firm has multiple media fill failures. They conducted their media fills using TSB (tryptic soy broth) prepared by filtration through a 0.2 micron sterilizing filter. Investigation did not show any obvious causes.What could be the source of contamination?

  5. What are the cleaning validation requirements for potent compounds (e.g., compounds that are cytotoxic, mutagenic, or have high pharmacologic activity), and is dedicated equipment required?

  6. How do I perform cleaning validation, including for homeopathic drug products?

  7. Does equipment need to be clean enough to meet limits based on the most sensitive possible methods of residue detection or quantification?

  8. Do firms need to quantify the total amount of residue remaining on equipment surfaces after manufacturing a product (before cleaning) to support cleaning validation studies?

  9. Should laboratory glassware be included in a firm's equipment cleaning validation program?

  10. What is an acceptable level of detergent residue, and what is the basis for arriving at this level, if any?

  11. If a procedure’s ability to clean a piece of equipment made of a particular material, such as 316 stainless steel, is acceptable and validated, can that “material-specific” cleaning procedure be applied to other pieces of equipment and compounds without extensive validation?

  12. Is testing rinse solution enough to support residue determinations for cleaning validation?

  13. Does FDA prefer one type of material over another (e.g., polyvinylidene difluoride over stainless steel) for construction of recirculating loops in water for injection (WFI) systems?

1. Many leading analytical balance manufacturers provide built-in "auto-calibration" features in their balances. Are such auto-calibration procedures acceptable instead of external performance checks? If not, then what should the schedule for calibration be?

The auto-calibration feature of a balance may not be relied upon to the exclusion of an external performance check (21 CFR 211.68). For a scale with a built-in auto-calibrator, we recommend that external performance checks be performed on a periodic basis, but less frequently as compared to a scale without this feature. The frequency of performance checks depends on the frequency of use of the scale and the criticality and tolerance of the process or analytical step. Note that all batches of a product manufactured between two successive verifications would be affected should the check of the auto-calibrator reveal a problem. Additionally, the calibration of an auto-calibrator should be periodically verified—a common frequency is once a year—using National Institute of Standards and Technology (NIST)-traceable standards or NIST-accredited standards in use in other countries.

References:

  • 21 CFR 211.68: Automatic, mechanical, and electronic equipment
  • 21 CFR 211.160(b)(4): General requirements (Laboratory Controls)
  • United States Pharmacopeia (USP) GeneralChapter <41> Weights and Balances
  • See alsoASTM Standard E 617, 2013,Standard Specification for Laboratory Weights and Precision Mass Standards, West Conshohocken, PA: ASTM International(This standard is incorporated into the USP by reference; other widely recognized standards may be acceptable.)


Date: 8/4/2004

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2. Is there a list of CDER-approved drug manufacturing equipment?

No. The CGMP regulations neither approve nor prohibit specific equipment for use in manufacturing of pharmaceutical products (with the exception of asbestos and fiber-releasing filters, see 21 CFR 211.72). We do not maintain a list of approved equipment. Firms are afforded the flexibility to select equipment that best satisfies their particular needs and that is capable of meeting the relevant CGMP requirements. Each firm is responsible for selecting all equipment used in their manufacturing process to produce quality products in accordance with CGMP.They are also responsible for selecting the appropriate intended use for the equipment's operation and are free to modify standard equipment designs to best suit their process and that are compatible with the product under process.

The CGMPs require that equipment be of appropriate design to facilitate operations for its intended use and for cleaning and maintenance (see 21 CFR 211.63 and 211.67) and, that any equipment surface in contact with components, in-process materials, or drug products not be reactive, additive, or absorptive so as to "alter the safety, identity, strength, quality, or purity of the drug product beyond the official or other established requirements" (see 21 CFR 211.65).

References:

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  • 21 CFR 211.63: Equipment design, size, and location
  • 21 CFR 211.65: Equipment construction
  • 21 CFR 211.67: Equipment cleaning and maintenance
  • 21 CFR 211.68: Automatic, mechanical, and electronic equipment
  • 21 CFR 211.72: Filters

Date: 5/18/2005

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3. Can Total Organic Carbon (TOC) be an acceptable method for detecting residues of contaminants in evaluating cleaning effectiveness?

Yes. Since the publication of the inspection guide on cleaning validation in 1993, a number of studies have been published to demonstrate the adequacy of TOC in measuring contaminant residues.

TOC or TC can be an acceptable method for monitoring residues routinely and for cleaning validation. In order for TOC to be functionally suitable, it should first be established that a substantial amount of the contaminating material(s) is organic and contains carbon that can be oxidized under TOC test conditions. This is an important exercise because some organic compounds cannot be reliably detected using TOC.

TOC use may be justified for direct surface sample testing as well as indirect (rinse water) sample testing. In either case, because TOC does not identify or distinguish among different compounds containing oxidizable carbon, any detected carbon is to be attributed to the target compound(s) for comparing with the established limit. Thus, a firm should limit background carbon (i.e., carbon from sources other than the contaminant being removed) as much as possible. The established limit, or the amount of residue detected for comparison to the specification, should correct for the target material’s composition of carbon. As for any cleaning method, recovery studies are necessary (21 CFR 211.160(b)).If TOC samples are being held for long periods of time before analysis, a firm should verify the impact of sample holding time on accuracy and limit of quantitation.

References:

  • 21 CFR 211.67: Equipment cleaning and maintenance

  • 21 CFR 211.160(b): General requirements (Laboratory Controls)

  • USP General Chapter <643> Total Organic Carbon

  • FDA Guide to Inspections: Validation of Cleaning Processes

Date: 5/18/2005

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4. A firm has multiple media fill failures. They conducted their media fills using TSB (tryptic soy broth) prepared by filtration through a 0.2 micron sterilizing filter. Investigation did not show any obvious causes. What could be the source of contamination?

A firm had multiple media fill failures. The media fill runs, simulating the filling process during production, were conducted inside an isolator. The firm used TSB (nonsterile bulk powder) from a commercial source and prepared the sterile solution by filtering through a 0.2 micron sterilizing filter. An investigation was launched to trace the source of contamination. The investigation was not successful in isolating or recovering the contaminating organism using conventional microbiological techniques, including the use of selective (e.g., blood agar) and nonselective (e.g., TSB and tryptic soy agar) media, and examination under a microscope. The contaminant was eventually identified to be Acholeplasma laidlawii by using 16S rRNA gene sequence. The firm subsequently conducted studies to confirm the presence of Acholeplasma laidlawii in the lot of TSB used. Therefore, it was not a contaminant from the process, but from the media source.

Acholeplasma laidlawii belongs to an order of Mycoplasma. Mycoplasma contain only a cell membrane and have no cell wall. They are not susceptible to beta-lactams and do not take up Gram stain. Individual organisms are pleomorphic (assume various shapes from cocci to rods to filaments), varying in size from 0.2 to 0.3 microns or smaller. It has been shown that Acholeplasma laidlawii is capable of penetrating a 0.2 micron filter, but is retained by a 0.1 micron filter (see Sundaram, Eisenhuth,et al. 1999). Acholeplasma laidlawii is known to be associated with animal-derived material, and microbiological media is often from animal sources. Environmental monitoring of Mycoplasma requires selective media (PPLO broth or agar).

Resolution:

For now, this firm has decided to filter prepared TSB, for use in media fills, through a 0.1 micron filter (note: we do not expect or require firms to routinely use 0.1 micron filters for media preparation). In the future, the firm will use sterile, irradiated TSB when it becomes available from a commercial supplier. (Firm's autoclave is too small to permit processing of TSB for media fills, so this was not a viable option.) The firm will continue monitoring for Mycoplasma and has revalidated their cleaning procedure to verify its removal. In this case, a thorough investigation by the firm led to a determination of the cause of the failure and an appropriate corrective action.

References:

  • 21 CFR 211.113: Control of microbiological contamination
  • 21 CFR 211.72: Filters
  • 21 CFR 211.84(d)(6): Testing and approval or rejection of components, drug product container, and closures
  • Sundaram, S, J Eisenhuth, G Howard, and H Brandwein, 1999, Application of Membrane Filtration for Removal of Diminutive Bioburden Organisms in Pharmaceutical Products and Processes, PDA J Pharm Sci Technol, 53(4):186–201
  • Kong, F, G James, S Gordon, A Zekynski, and GL Gilbert, 2001, Species-Specific PCR for Identification of Common Contaminant Mollicutes in Cell Culture, Appl Environ Microbiol, 67(7):3195–3200
  • Murray, P, E Baron, M Pfaller, F Tenover, and R Yolken, 1995, Manual of Clinical Microbiology, 6th ed., Washington, DC: ASM Press

Date: 5/18/2005

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5. What are the cleaning validation requirements for potent compounds (e.g., compounds that are cytotoxic, mutagenic, or have high pharmacologic activity), and is dedicated equipment required?

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Separation or dedication of equipment and facilities for the manufacture of potent compounds is not specifically required by CGMP regulations. However, manufacturers should identify drugs with such risks and define the controls necessary to eliminate risk of product cross-contamination in nondedicated equipment and facilities. Such controls include proper cleaning, cleaning validation, and other contaminant controls. Firms must validate that cleaning procedures are adequate to ensure that cross-contamination does not occur. CGMP regulations establish requirements to guide development and execution of cleaning validation plans.

In designing a facility, firms should carefully evaluate manufacturing processes to determine the best procedural controls and floor plan—optimizing the flow of materials, equipment, and people—to help prevent product contamination.

References:

  • 21 CFR 211.42: Design and construction features
  • 21 CFR 211.67: Equipment cleaning and maintenance

Date: 6/8/2015

6. How do I perform cleaning validation, including for homeopathic drug products?

21 CFR 211.67(a) requires that any equipment, including dedicated and multipurpose equipment, is “cleaned, maintained, and, as appropriate for the nature of the drug, sanitized and/or sterilized at appropriate intervals to prevent malfunctions or contamination that would alter the safety, identity, strength, quality, or purity of the drug product beyond the official or other established requirements.” You must therefore ensure that residues (e.g., active ingredients, cleaning agents) are adequately removed from product contact surfaces of all equipment during product changeovers and/or between production campaigns, depending on the types of materials and surfaces in use.

Cleaning procedures should be well-documented and consistent for their intended use. Cleaning validation programs should provide assurance that residues are effectively removed from product contact surfaces, and manufacturers should select test methods that demonstrate their effectiveness. FDA does not provide extensive guidance on conducting cleaning validation but does recommend consulting guidelines published by various trade and professional associations for additional information (e.g., International Society for Pharmaceutical Engineering, Parenteral Drug Association).

Reference:

  • 21 CFR 211.67: Equipment cleaning and maintenance

Date: 6/8/2015

7. Does equipment need to be clean enough to meet limits based on the most sensitive possible methods of residue detection or quantification?

No. CGMPs require that equipment be cleaned to prevent contamination that “would alter the safety, identity, strength, quality, or purity of the drug product beyond the official or other established requirements” (see 21 CFR 211.67). The preamble to the CGMP regulations (see 43 FR 45014) indicates that this phrase was added because absolute cleanliness for multiuse equipment is neither valuable nor feasible in many circumstances. The degree of cleanliness needed, therefore, cannot depend on the method of detection because improvements in method sensitivity would necessitate ever-lower limits and ever-increasing wash cycles. Equipment should be as clean as can be reasonably achieved to a residue limit that is documented to be safe, causes no product quality concerns, and leaves no visible residues. Contamination that is reasonably avoidable and removable is never considered acceptable.

References:

  • 21 CFR 211.67: Equipment cleaning and maintenance
  • Preamble to the Current Good Manufacturing Practice final regulations (43 FR 45014, Sept 29, 1978)

Date: 6/8/2015

8. Do firms need to quantify the total amount of residue remaining on equipment surfaces after manufacturing a product (before cleaning) to support cleaning validation studies?

No. In validating original cleaning procedures, firms need not quantify the level of chemical contamination remaining after manufacturing a product and before cleaning. Firms must, however, ensure that they validate proposed cleaning procedures as for routine use and should not pre-clean or otherwise attempt to make it easier for the procedures being validated to meet their cleaning objectives.

For example, batches significantly smaller than full-scale would not offer sufficient assurance that the cleaning procedure could reliably remove residues to acceptable levels after full-scale production. The material being cleaned should be manufactured at a similar scale and manner as during validation. Also, firms should sample equipment that is stored uncleaned for a longer time than validated to demonstrate that their cleaning procedures are effective.

Once equipment surfaces are cleaned by validated procedures, firms generally are not expected to analytically examine them after each cleaning. (Manual cleaning methods may be an exception to this general rule because of inherent variability in operator compliance and abilities.) However, a residue-monitoring program whose frequency and methods have been determined by risk assessment is recommended.

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Reference:

  • FDA Guide to Inspections: Validation of Cleaning Processes

Date: 6/8/2015

9. Should laboratory glassware be included in a firm's equipment cleaning validation program?

No. FDA does not expect laboratory glassware to be included in the processing equipment cleaning validation program. Glassware must, of course, be clean, and CGMP regulations consider laboratory equipment to be included within the scope of 21 CFR 211.67. Cleanliness is best assessed by inspecting laboratory procedures for the following:

  • Use of nondedicated glassware and other equipment
  • Method validation (e.g., ruggedness)
  • Absence of extraneous or interfering data in the results of sample analyses

Laboratory cleaning procedures may include repetitive rinses with the solvent used to prepare the analyte, followed by oven drying. The equipment need not be swabbed or otherwise tested to ensure removal of potentially contaminating residues. A firm may elect to sample its glassware for residual contamination to exclude or explore the possibility of interference in the case of particularly sensitive analyses or difficult-to-clean compounds.

The possibility of carryover contamination affecting a method’s performance or integrity of the results is generally considered of low risk to the product and consumers, with the exception of potent compounds. Contaminated laboratory equipment, however, should not be a frequent excuse for rejecting or discarding aberrant results. Glassware that is not properly cleaned can make it difficult to determine if the source of aberrant analytical results is related to the unclean glassware or residues from manufacturing equipment. We expect firms to maintain laboratory equipment in a clean and sanitary manner to provide confidence in the analytical results.

Reference:

  • 21 CFR 211.67: Equipment cleaning and maintenance

Date: 6/8/2015

10.What is an acceptable level of detergent residue, and what is the basis for arriving at this level, if any?

It is the firm’s responsibility to establish acceptance limits and to be prepared to provide the basis for those limits to FDA. Thus, there is no universal standard for levels of detergent residue. Residues must not exceed their established acceptance limits and must not adversely alter drug product safety, efficacy, quality, or stability (see references below).

References:

  • 21 CFR 211.67: Equipment cleaning and maintenance

  • FDA Guide to Inspections:Validation of Cleaning Processes

Date: 6/8/2015

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11. If a procedure’s ability to clean a piece of equipment made of a particular material, such as 316 stainless steel, is acceptable and validated, can that “material-specific” cleaning procedure be applied to other pieces of equipment and compounds without extensive validation?

No. In establishing an effective cleaning procedure for a particular piece of equipment, firms must consider its material of construction/fabrication, exact design, conditions of use, and, in particular, the specific substances that could contaminate the equipment. Therefore, to demonstrate proof of cleaning for a given piece of equipment, firms should have data that relate to all of these factors.

References:

  • 21 CFR 211.67: Equipment cleaning and maintenance

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  • FDA Guide to Inspections:Validation of Cleaning Processes

Date: 6/8/2015

12. Is testing rinse solution enough to support residue determinations for cleaning validation?

No. For cleaning validation, rinse samples alone would not be acceptable; firms should also measure the residue or contaminant on the equipment surface using a direct method (if feasible). One disadvantage of rinse samples is that the rinse solvent may not remove the residue or contaminant. Rinse samples are capable of sampling large surface areas, particularly ones that are difficult to access; therefore, some firms use both swab and rinse samples during the course of their cleaning validation. This is acceptable if the rinse solvent has been demonstrated to dissolve residues of concern and is otherwise suitable for use on the surfaces to be sampled.

For routine equipment cleaning after validation, a residue-monitoring program whose frequency and methods have been determined by risk assessment is recommended to demonstrate that the validated process continues to consistently clean the equipment.

The purpose of cleaning validation is to demonstrate that a particular cleaning process will consistently clean the equipment to a predetermined standard; the sampling and analytical test methods should be scientifically sound and should provide adequate scientific rationale to support the validation.

References:

Date: 6/8/2015

13. Does FDA prefer one type of material over another (e.g., polyvinylidene difluoride over stainless steel) for construction of recirculating loops in water for injection (WFI) systems?

No. There is no official agency preference for one material over another. Whatever material a firm selects for its WFI system must be suitable for its intended use. This holds true for virtually all production equipment.

When evaluating the suitability of a WFI system’s piping, consider the surface texture or finish of the piping’s interior wall (e.g., smoothness, waviness), its ability to resist high temperatures and pressures, and its ability to withstand sterilizing and sanitizing agents and procedures.

Equipment surfaces that are in contact with components, in-process materials, or drug products must not be reactive, additive, or absorptive so as to alter the drug product’s safety, identity, strength, quality, or purity beyond its official or established requirements.

References:

  • 21 CFR 211.65: Equipment construction
  • 21 CFR 211.67: Equipment cleaning and maintenance

Date: 6/8/2015

Contact for further information:

CDER-OPQ-Inquiries@fda.hhs.gov

Home | General Provisions | Buildings and Facilities | Equipment | Control of Components and Drug Product Containers and Closures | Production and Process Controls | Holding and Distribution | Laboratory Controls | Records and Reports | Returned and Salvaged Drug Products

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FAQs

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Human monkeypox (MPX) is a zoonotic viral disease caused by the monkeypox virus (MPXV).. Since it was first recognised as a human disease in 1970, MPX cases have been increasingly reported in several African countries due to a combination of factors including both increased exposure (deforestation, conflict and displacement), as well as improved surveillance and laboratory capacity in the African region.. Unlike previous monkeypox cases in Europe, most subsequent cases in the current outbreak have no travel history to parts of West- and Central Africa where monkeypox is endemic.. Some of the current cases attended the same events in different EU countries, where they had close or sexual contact with others.. The disease is more likely to spread through close contacts, for example during sexual activities, and in this group the risk can be considered high.. The likelihood of MPX spreading in people who have multiple sexual partners, including some groups of men who have sex with men (MSM), is considered high in the EU/EEA.. Human-to-human transmission occurs through close contact with infectious material from skin lesions of an infected person, through respiratory droplets in prolonged face-to-face contact, and through fomites.. The predominance, in the current outbreak, of diagnosed human MPX cases among men who have sex with men, and the nature of the presenting lesions in some cases, suggest transmission occurred during sexual intercourse.. Infected people should remain isolated until scabs fall off and should especially avoid close contact with immunosuppressed persons and pets.. Close contacts of monkeypox cases should self-monitor for the development of symptoms for 21 days after the last exposure and should avoid close physical contact with young children, pregnant women and immunocompromised persons until MPX is excluded.. Condoms alone cannot provide full protection against transmission of MPXV as contact with skin lesions may be sufficient for transmission to occur.. Given the unusually high frequency of human-to-human transmission observed in the past weeks, and the probable community transmission without a history of travel to endemic areas, the likelihood of further spread of the virus through close contact, for example during sexual activities, is considered to be high.. It can be used for pre- and post-exposure prophylaxis (PEP) of close contacts at increased risk for severe disease.. Before, cases were sporadically imported and were related to travel to endemic countries, whereas in these outbreaks, we see an unusual incidence of cases infected in the community without travel links.. In addition, it is disproportionally affecting specific groups, i.e. men who have sex with men, probably because of close or sexual contact during recent events.

Want to deliver a rocking history quiz night? We’ve got the best history quiz questions and answers for your Zoom, House Party or online quiz.

We’ve got you covered – as a group of wannabe historians, we’ve put together what we think are 100 of the best history quiz questions and answers.. From the easiest of quizzes to hard history quiz questions, we’ve put together ten rounds that will hopefully have your contestants scratching their heads in historical delight.. Whether it’s for a real-life quiz night or virtual home pub quiz for Zoom, House Party or even Skype, you’ll find all the history quiz questions you need.. So, get those quiz cockles warmed up with this opening round of what we can only term funny history quiz questions.. The monarchs are a rich territory for pub quizzes, so why not give your participants a royal dose of history questions and answers related to kings and queens of the British empire; whether that’s England, Wales, Scotland or Northern Ireland.. King Henry IV, King Henry V and King Henry VI were members of which royal house?. Kings and Queens – British History Quiz Answers. Easy History Quiz Round Answers. Now we’ve covered two of the most prominent countries in world history – the United Kingdom and the United States – it’s time to go global.. It was a difficult time in world history, but World War II is often one of those events that sparks a lot of quiz questions, and you can’t really do a history trivia quiz without out.. So, with that in mind, we’ve put together ten of the best history quiz questions and answers about the second World War.. Great even for some family history quiz questions, let’s see how your participants do in answering these buccaneer-themed brainteasers:. So, what did you think of our History Quiz Questions and Answers?

Here's a list of carefully selected and thought-provoking general trivia questions culled from various subjects; alongside their answers.

Which country of the world has the largest population?. The East Asian country is the world’s most populous country with a population of more than 1.402 billion as of 2020.. It is also the longest river in South American and according to some sources, the longest river in the world as well.. Often called the capital of the world, New York City is the most populous city in the United States, one of the world’s most populous megacities, and the most ethnically diverse urban area in the world.. The American military officer and politician was the 9th president of the United States but he died in office 31 days after his inauguration and made history as the shortest presidency in the history of the United States.. The South American country would win their second world cup two decades later: they defeated Brazil 2 – 1 to win the FIFA World Cup of 1950.. No citizen of the North American nation should be told that the United States of America is a federal republic made up of 50 states with a federal district, Washington, D.C., which is the capital city of the country.. This is probably the easiest question to answer among the general trivia questions listed here.. Which country is the largest in the world?. Which country is the smallest in the world?. Which capital city of the world is located on the Tiber River?. What is the most visited country in the world?. If you are looking for hard general trivia questions to answer, this should make your list.. This is one of the general trivia questions that are hard for people to answer but Nicaragua and Dominica are the only countries with the color in their flags.

Easy trivia questions and answers that are fun for friends, family, colleagues, and much more. Easy to solve, but tons of fun to be had!

From movies to music artists to food to geography and nearly anything else you could think of, here are easy trivia questions (and answers) to ask family and friends during a trivia night .. Answer: Soccer/football. Answer: 206. Answer : 6. Answer: 9. Answer: 366. Answer: 1959. Answer: 3. Answer: 9. Answer: Magic/illusion. Answer: 2007. Answer: 12. Answer: C.S.. Answer: 27

Perfect for parties, social gatherings, pub quizzes or school groups. Test yourself with these 100 fun and free quiz questions with answers.

Kew Gardens Which popular gardener created Barnsdale Gardens and was the author of many books such as The Ornamental Kitchen Garden , Paradise Gardens and Gardeners World: Practical Gardening Course ?. Blue Which organic gardener is almost as famous for his long blond plait as he is for his books such as Going Organic and The Gourmet Gardener, as well as his regular appearances on the BBC radio's Gardener's Question Time ?. I like your questions it was very interesting thank you Adele. It would be a dull quiz if the questions were too easy.. i found these questions and answers not that helpful because i don't think my family would know those questions (:. I am using a few of you questions to add to my family quiz.. I love these quiz questions. The largest island question should have read..."What is the world's largest island that is not considered a continent?". Thanks for these trivia questions Adele.. I am definitely including this Question in my next family video conference quiz just to engage some discussion - and no one is likely to get it right (ha ha).. This quiz is what it sounds like: A QUIZ!. The quiz is very interesting and a bit complex.I actually really enjoy the quiz,it is very educating and enlightening.Thank you very much Adele.. Australia is classed as a continent and therefore, by definition, cannot also be classed as an island - therefore Greenland is correctly classed as worlds largest island

Random trivia questions and answers are really fun, amusement GK full of learning materials from all walks of life. Quiz, general knowledge

What is the name of both the longest river in Italy and the Teletubbies character?. On which day of the week to be Christmas Day 2021?. The Aegean Sea is located between which two countries?. In just one day, a person may blink their eyes over 11,500 times.. Which year was the last time England failed to qualify for the World Cup?. The iron present in our blood forms a ring of atoms called porphyrin, the shape of this structure produces the red colour.. Atticus Finch is a fictional character in which Pulitzer Prize-winning novel?. Which player who’s not British or Irish has the most Premier League Championship Medals?. random trivia quiz questions and answersrandom quiz questions and answersrandom general knowledge questions and answersrandom trivia questions with number answersrandom quiz questions with answersrandom trivia categoriesrandom trivia with answersrandom pub quiz questions and answersrandom general knowledge triviarandom trivia generator multiple choicerandom knowledge questions and answersrandom knowledge quiz with answersrandom trivia and answersrandom facts quiz with answersrandom quiz with answers10 random quiz questions and answersrandom quiz and answersrandom trivia easyrandom questions and answers funnytrivia random questions and answersrandom facts quiz and answerseasy miscellaneous trivia questions and answersfun random trivia questions and answersrandom knowledge quiz questions and answersrandom history trivia questions and answersrandom trivia questions and answers multiple choicerandom general knowledge quiz questions and answersrandom facts quiz questions and answersrandom trivia quiz and answersrandom knowledge trivia questions and answersrandom facts trivia questions and answersrandom trivia quiz multiple choicerandom trivia questions and answers easyrandom trivia questions and answers printablerandom friends trivia questions and answersrandom trivia questions and answers for adultsfunny random questions and answersrandom funny quiz questions and answersrandom general knowledge questions with answersrandom sports trivia questions and answers

Sometimes, even when you know a lot of English, you can have difficulty finding the right words or phrases to answer simple questions. Here are 20 of the most common questions in English - each one with five sample responses.

This question means “What is your job/profession?”. https://www.espressoenglish.net/wp-content/uploads/2013/04/100-answers2.mp3 Yes, I’ve been married for two years now.. https://www.espressoenglish.net/wp-content/uploads/2013/04/100-answers5.mp3 I don’t have any free time!. “Hang out” means to spend time in an informal way.. Normally when people ask “how’s it going?” they expect a positive response like “fine” or “good.” If you say “Do you really wanna know?” it means that things are going badly, but you are not sure if the other person wants to listen to your problems or not.. You can say you’re feeling “awful” for both physical and emotional pain.. https://www.espressoenglish.net/wp-content/uploads/2013/04/100-answers15.mp3 I’ve been working a lot.. This means “relaxing, not doing anything intense or stressful.” Planning my summer vacation.. To “order” means to ask the waiter/waitress for the food you want to eat.. https://www.espressoenglish.net/wp-content/uploads/2013/04/100-answers18.mp3 Not quite – I think we need a little more time.. While you are eating, the waiter/waitress will often come to your table and ask this question to check if you need anything.. The “check” is the list of items and the total price to pay.

Make learning fun with these trivia questions for kids with answers. These engaging questions are great for improving your kid's knowledge and intellect.

Want to make your kids scratch their heads to find the answers?. Let’s ease them with some random trivia questions which kids can answer as they pop the fruits.. Let them warm up a bit and freshen up their minds for the energetic and kid-friendly sports trivia questions and answers.. 54. Who has been named as the White Lightning in the game of cricket?. Then it is time to dive into some history trivia questions, to get some crunchy answers from their whispering tongues.

Random trivia questions are a fun way to spend time with people you love and here is a selection of 35 guaranteed interesting questions with their answers

So, the next time you are thinking of a fun way to spend time with whichever group of persons, you can make use of any of our icebreaker questions or these random trivia questions and their answers below.. What is the name of the world’s largest island?. Aside from being the largest Island in the world, the island contains the oldest known rocks on the planet, which is approximately 3.8 million years old.. Alexander Graham Bell was a Scottish scientist, inventor, and engineer who was credited as the inventor of the first practical telephone.. Name the world’s largest ocean.. What is the highest mountain in Africa called?. How many rings make up the symbol of the Olympic Games?. Which UK Cities cities have underground rail systems?. Lady Gaga was born Stefani Joanne Angelina Germanotta on 28 March 1986 in New York City, United States.. By additively mixing colors red, yellow, and blue in varying amounts, almost all other colors can be produced.. Answer: Mr.

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